medchem-express - Biotutkimukseen ja diagnostiikkaan

MCE:n  (MedChem Express) valikoima käsittää laajan valikoiman tutkimusbiokemikaaleja, vasta-aineita, referenssiyhdisteitä, farmaseuttisten yhdisteiden aktiivisia komponentteja (API) ja luonnontuotteiden yhdisteitä.                                                         
Nyt myös oligonukleotidejä ja geenejä.
Yli 30 000 selektiivistä inhibiittoria ja agonistia, yli 10 000 rekombinanttiproteiinia, yli 170 seulontakirjastoa, joissa
n.16 miljoonaa yhdistettä.
Erityistä huomiota on kiinnitetty tuotteiden puhtauteen, pysyvyyteen ja aktiivisuuteen.
Useimpia tuotteita saatavana suoraan varastosta.

Viimeisimpiä julkaisuja, joissa käytetty MCE:n tuotteita


Nat Med.
2023 Sep;29(9):2295-2306.

2023 Sep;621(7977):188-195.

2023 Aug 31;186(18):3903-3920.e21.

Cancer Cell.
2023 Sep 11;41(9):1621-1636.e8.

CAS No.: 2259860-24-5
Research Area:      
A fully human IgG4 anti-PD-1 monoclonal antibody with an EC50 of 210 pM for human PD-1.
Effectively blocks the binding of PD-L1 and PD-L2 to cell-surface PD-1 in CHO-S cells, with IC50 values of 580 pM and 670 pM, respectively.
Used for the research in various cancers, including cervical cancer, non-small cell lung cancer and classical Hodgkin’s lymphoma.
Solubility: Solution: 5.35 mg/mL
CAS No.: 2764609-97-2
Research Area:      
BTK/FLT3/Hematological Malignancies
A potent BTK and FLT3 inhibitor with IC50 values of 47 nM and 12 nM, respectively.
Effectively inhibits the proliferation of multiple hematological malignancy cells, and induces apoptosis in jeko-1 cells.
Demonstrates anti-tumor activity and well-tolerated in jeko-1 and MV4-11 xenograft models.
Solubility: DMSO: 83.33 mg/mL (190.91 mM; Need ultrasonic)
CAS No.: 912569-84-7
S-methyl DM1
Research Area:       
Microtubule/Tubulin/Breast Cancer                             
A thiomethyl derivative of Maytansine, binds to tubulin with
a Kd of 0.93 μM.
Inhibits microtubule polymerization and potently suppresses microtubule dynamic instability.
Shows anticancer effects and can be used in the synthesis of antibody-drug conjugates (ADCs).
Solubility: DMSO: 100 mg/mL (132.92 mM; Need ultrasonic)
CAS No.: 2640647-90-9
Research Area:      
An orally active BCL6 inhibitor (IC50 of 6 nM) with potent antiproliferative effects in vitro.
Effectively inhibits tumor growth in a lymphoma xenograft mouse model.
Solubility: DMSO: 100 mg/mL (221.81 mM; Need ultrasonic)
CAS No.: 154554-41-3
Research Area:      
A tubulin polymerization (IC50 of 0.68 µM) inhibitor with antimitotic and antitumor activities.
An apoptosis inducer that induces translocation of apoptosis inducing factor (AIF) from the mitochondria to nucleus.
Reduces tumor volume and increases survival of mouse in an HA22T xenograft model.
Solubility: DMSO     : 5 mg/mL (17.65 mM; Need ultrasonic)
Oligosaccharides are sugars that consist of monosaccharides (usually 2-10) units connected by glycosidic bonds to form straight or branched chains. According to the different types of monosaccharides,  intermolecular binding positions and binding types, there are more than thousands of kinds of oligosaccharides. It is a new type of functional sugar source, which integrates nutrition, health care and diet therapy, and is widely used in food, health care products, beverages, medicine, feed additives and other fields.
D-Tetramannuronic acid
Used for the research of pain and vascular dementia.
L-Hexaguluronic acid
A linear polysaccharide copolymer composed of six L-guluronic acid (G).
A human milk oligosaccharide that prevents necrotising enterocolitis in neonatal rats.
A sialylated human milk oligosaccharide that can promote the proliferation of bifidobacteria and shaping the gut microbiota.
A significant core structure of human milk oligosaccharides (HMOs) naturally existing in human milk, with prebiotic, immune regulatory, anti-inflammatory, intestinal cell responses regulatory, antibacterial and antiviral activities.
Serine/Threonine Kinase     Inhibitor Library
Protein phosphorylation is a key link in regulating many cellular processes such as cell division, metabolism and signal transduction. Protein serine/threonine kinases (PSKs) regulate protein phosphorylation by transferring phosphate groups to serine/threonine residues of substrate molecule. At present, abnormal activation of kinases has been confirmed to be involved in many disease processes, and has become  an important therapeutic target for tumors, inflammation and other diseases. Serine/Threonine kinase inhibitors have also become an indispensable class of tool compounds, which widely used in research on cancer, chronic inflammation, autoimmune diseases, etc.
MCE designs a unique collection of 1,100+ serine/threonine kinase inhibitors, mainly targeting the receptor PKA, Akt, PKC, MAPK/ERK, etc, which is an effective tool for development and research of anti-cancer, anti-chronic inflammatory diseases, anti-autoimmune diseases and anti-aging compounds.
MCE Isotope-labeled Compounds
Cat. No.                  
3-Iodothyronamine-d4 hydrochloride
4'-Hydroxy diclofenac-d4       

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